Rapid advances in genomics, screening technologies, and personalised risk assessment are reshaping how health systems predict, prevent, and manage disease. This track highlights key developments in precision health, beginning with insights from the SG100k project—Singapore’s large scale Asian reference genome initiative—which is generating population specific data to improve risk stratification, diagnostics, and treatment relevance for Asian communities. Sessions will explore the expanding role of genetic screening in identifying inherited risks early, enabling more targeted and proactive care pathways. Precision approaches in cancer care will be showcased, illustrating how genomic profiling and molecular diagnostics can guide therapy choices and improve outcomes. The track will also address precision screening in ophthalmology, highlighting innovations in early eye disease detection and personalised prevention strategies. Together, these discussions offer a forward looking view of how precision health can transform population health through more tailored, data driven care.